Home

Humalog mix

Clinical studies of Humalog Mix50/50 did not include sufficient numbers of patients aged 65 and over to determine whether they respond differently than younger patients. In general, dose selection for an elderly patient should take into consideration the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy in this population.Talk to your healthcare provider if you have any questions. Your healthcare provider will tell you the right syringes to use with Humalog Mix50/50 vials. Your healthcare provider should show you how to inject Humalog Mix50/50 before you start using it. Read the User Manual that comes with your Humalog Mix50/50 prefilled pen.Pain, redness, swelling or itching at the injection site may occur. These effects usually go away after a few days or weeks. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.Insulin lispro has the empirical formula C257H383N65O77S6 and a molecular weight of 5808, both identical to that of human insulin.Adjustment of dosage of any insulin may be necessary if patients change their physical activity or their usual meal plan. Insulin requirements may be altered during illness, emotional disturbances, or other stress.

Humalog Warnings! - Read Before Take I

  1. Advise patients that hypersensitivity reactions have occurred with HUMALOG Mix75/25. Inform patients on the symptoms of hypersensitivity reactions and to seek medical attention if they occur [see Warnings and Precautions (5.5)].
  2. utes before eating or right after eating a meal. Always make sure you receive the correct type of Humalog from the pharmacy. Do not use Humalog if it is cloudy, colored, or has solid particles or clumps in it. Do not mix Humalog U-200 with any other insulin
  3. Use Humalog Mix50/50 only to treat your diabetes. Do not share it with anyone else, even if they also have diabetes. It may harm them.
  4. The primary activity of insulin, including HUMALOG Mix75/25, is the regulation of glucose metabolism. Insulins lower blood glucose by stimulating peripheral glucose uptake by skeletal muscle and fat, and by inhibiting hepatic glucose production. Insulins inhibit lipolysis and proteolysis, and enhance protein synthesis.
  5. Never mix Humalog U-200, Humalog Mix75/25, or Humalog Mix50/50 with other insulins or liquids. Never use Humalog U-200, Humalog Mix75/25, or Humalog Mix50/50 in a pump. Do not drive or operate heavy machinery until you know how Humalog U-100, Humalog U-200, Humalog Mix75/25, Humalog Mix50/50, or Insulin Lispro Injection affects you
  6. Humalog Mix 75/25 was associated with a smaller rise in glucose levels after participants ate breakfast and dinner meals. o The average rise in post-breakfast glucose levels for Humalog Mix75/25 was 18 mg/dL compared to 47 mg/dL for Lantus
Humalog Mix 75/25 - FDA prescribing information, side

JDRF Foundation Official Site - How to Pay For Insuli

  1. Accidental mix-ups between HUMALOG Mix50/50and other insulin products have been reported. To avoid medication errors between HUMALOGMix50/50and other insulins, instruct patients to always check the insulin label before each injection. 5.5 Hypersensitivity Reaction
  2. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.
  3. Patients and caregivers must be educated to recognize and manage hypoglycemia. Self-monitoring of blood glucose plays an essential role in the prevention and management of hypoglycemia. In patients at higher risk for hypoglycemia and patients who have reduced symptomatic awareness of hypoglycemia, increased frequency of blood glucose monitoring is recommended.

Read the Patient Information that comes with Humalog Mix50/50 before you start using it and each time you get a refill. There may be new information. This leaflet does not take the place of talking with your healthcare provider about your diabetes or treatment. Make sure that you know how to manage your diabetes. Ask your healthcare provider if you have questions about managing your diabetes.Humalog differs from Regular human insulin by its rapid onset of action as well as a shorter duration of activity. Therefore, the dose of Humalog Mix50/50 should be given within 15 minutes before a meal. Studies in nondiabetic subjects and patients with type 1 (insulin-dependent) diabetes demonstrated that Humalog, the rapid-acting component of Humalog Mix50/50, is absorbed faster than Regular human insulin (U-100). In nondiabetic subjects given subcutaneous doses of Humalog ranging from 0.1 to 0.4 U/kg, peak serum concentrations were observed 30 to 90 minutes after dosing. When nondiabetic subjects received equivalent doses of Regular human insulin, peak insulin concentrations occurred between 50 to 120 minutes after dosing. Similar results were seen in patients with type 1 diabetes.

Buy Reusable Insulin Cooler Pen Cap - VIVI CAP1 for Eli Lilly KwikPen: Humalog, Humalog Mix, Humulin, Basaglar | FDA Registered | for Everyday, Travel & Emergency kit | Years Without Any Maintenance on Amazon.com FREE SHIPPING on qualified order Thiazolidinediones (TZDs), which are peroxisome proliferator-activated receptor (PPAR)-gamma agonists, can cause dose-related fluid retention, particularly when used in combination with insulin. Fluid retention may lead to or exacerbate heart failure. Patients treated with insulin, including HUMALOG Mix75/25, and a PPAR-gamma agonist should be observed for signs and symptoms of heart failure. If heart failure develops, it should be managed according to current standards of care, and discontinuation or dose reduction of the PPAR-gamma agonist must be considered. Humalog (active ingredient - insulin lispro) is a medication that is used to treat type 1 diabetes in adults and children who are at least 3 years old. It is a fast-acting insulin which starts to work about 15 minutes after injection and keeps working for 2 to 4 hours Humalog Mix 50/50 (50% insulin lispro protamine suspension and 50% insulin lispro injection (rDNA ORIGIN) is a hormone produced in the body used to treat type 1 (insulin-dependent) diabetes in adults. Humalog Mix 50/50 is usually given together with another long-acting insulin. Common side effects of Humalog Mix 50/50 include Humalog® Mix75/25™ and Humalog® Mix50/50™ are combinations of fast- and longer-acting insulins that work together to help manage your blood sugar between meals and at night, as well as blood sugar "spikes" that can happen when you eat.

Low blood sugar (hypoglycemia) is a possible side effect of insulin that may be severe and cause seizures or death. Signs and symptoms of low blood sugar may include dizziness or light-headedness, sweating, confusion, headache, blurred vision, slurred speech, shakiness, fast heartbeat, anxiety, irritability, mood changes, or hunger. HUMALOG® Mix50/50™ KwikPen™ (“Pen”) is a disposable pen containing 3 mL (300 units) of U-100 HUMALOG® Mix50/50™ [50% insulin lispro protamine suspension and 50% insulin lispro injection (rDNA origin)] insulin. You can inject from 1 to 60 units in a single injection.Safety and effectiveness of Humalog Mix50/50 in patients less than 18 years of age have not been established.   Not In-Use (Unopened) Room Temperature [Below30°C (86°F)] Not In-Use (Unopened) Refrigerated In-Use (Opened) Room Temperature [Below30°C (86°F)] 10 mL Vial 28 days Until expiration date 28 days,refrigerated/room temperature. 3 mL Pen and KwikPen (prefilled) 10 days Until expiration date 10 days. Do not refrigerate.

Insulin lispro protamine/insulin lispro is used along with a proper diet and exercise program to control high blood sugar in people with diabetes. This product is a combination of two man-made insulins: intermediate-acting insulin lispro protamine and rapid-acting insulin lispro. This combination starts working faster and lasts for a longer time than regular insulin.Changes in your lifestyle or activity level may affect the amount of insulin your body needs to control blood sugar. If you notice an unusual change in your insulin needs, tell your doctor.HUMALOG Mix75/25 KwikPens must never be shared between patients, even if the needle is changed. Patients using HUMALOG Mix75/25 vials must never share needles or syringes with another person. Sharing poses a risk for transmission of blood-borne pathogens.

75/25 & 50/50 Mixes Humalog

Humalog mixes start working faster than other insulins that contain regular human insulin. It's important to take Humalog mixes within 15 minutes before eating a meal to help prevent low blood sugar.Absorption — HUMALOG Mix75/25 has two phases of absorption. The early phase represents insulin lispro and its distinct characteristics of rapid onset. The late phase represents the prolonged absorption of insulin lispro protamine suspension. lispro [Humalog Mix 75/25], insulin aspart protamine/insulin aspart [NovoLog Mix 70/30]) Convert unit -per unit.3,12,13 Premix analogs have a faster onset but similar duration compared to human premixes. See Comparison of Insulins and Injectable Diabetes Meds for specifics of meal timing. 1 Premixed protamine/rapid -acting analog (insuli Humulin R is a brand name for regular insulin. It is a short-acting insulin. That means that it takes about 30 minutes to reach your bloodstream and works for about three to six hours

Video: Humalog Mix: Side Effects, Dosage & Uses - Drugs

Turn the Dose Knob to select the number of units you need to inject. The Dose Indicator should line up with your dose. Meet Fiasp: the latest addition to mealtime (fast-acting) insulins. While Fiasp insulin is still in the aspart category like Novolog, Apidra, and Humalog, it's a different insulin -- and it may not be ideal for everyone. Manufactured by Novo Nordisk, Fiasp starts working in your body within four minutes. While we o After first use (opened), store vial in the refrigerator (not the freezer) or, if necessary, at room temperature below 86°F (30°C). Do not use if vial has been frozen.Copyright © 2020 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. See additional information.Insulin lispro was not mutagenic in the following genetic toxicity assays: bacterial mutation, unscheduled DNA synthesis, mouse lymphoma, chromosomal aberration and micronucleus assays.

If you use an injection pen, use only the injection pen that comes with Humalog Mix. Attach a new needle before each use. Do not transfer the insulin from the pen into a syringe. Humalog Mix 25. Humalog Mix 25 may be available in the countries listed below. Ingredient matches for Humalog Mix 25 Insulin Injection, Protamine Zinc. Insulin Injection, Protamine Zinc is reported as an ingredient of Humalog Mix 25 in the following countries: Belgium; Insulin Lispr Tell your doctor if you also take pioglitazone or rosiglitazone (sometimes contained in combinations with glimepiride or metformin). Taking certain oral diabetes medicines while you are using insulin may increase your risk of serious heart problems.Renal Impairment — The effect of renal impairment on the pharmacokinetics and pharmacodynamics of Humalog Mix50/50 has not been studied. In a study of 25 patients with type 2 diabetes and a wide range of renal function, the pharmacokinetic differences between Humalog and Regular human insulin were generally maintained. However, the sensitivity of the patients to insulin did change, with an increased response to insulin as the renal function declined. Careful glucose monitoring and dose reductions of insulin, including Humalog Mix50/50, may be necessary in patients with renal dysfunction.

Insulin requirements may be decreased in the presence of drugs that increase insulin sensitivity or have hypoglycemic activity, such as oral antidiabetic agents, salicylates, sulfa antibiotics, certain antidepressants (monoamine oxidase inhibitors), angiotensin-converting-enzymeinhibitors, angiotensin II receptor blocking agents, beta-adrenergic blockers, inhibitors of pancreatic function (e.g., octreotide), and alcohol. Beta-adrenergic blockers may mask the symptoms of hypoglycemia in some patients.The rate of insulin absorption and consequently the onset of activity are known to be affected by the site of injection, exercise, and other variables. As with all insulin preparations, the time course of action of Humalog Mix50/50 may vary considerably in different individuals or within the same individual. Patients must be educated to use proper injection techniques.Inactive ingredients: protamine sulfate, glycerin, dibasic sodium phosphate, metacresol, zinc oxide (zinc ion), phenol and water for injection. Humalog ® Mix 75/25™ [75% insulin lispro protamine suspension and 25% insulin lispro injection, (rDNA origin)] is a mixture of insulin lispro solution, a rapid-acting blood glucose-lowering agent and insulin lispro protamine suspension, an intermediate-acting blood glucose-lowering agent. Chemically, insulin lispro is Lys(B28), Pro(B29) human insulin analog, created when the amino acids at. You will need to discard your Humalog Mix75/25 KwikPen and Humalog Mix50/50 KwikPen after 10 days in use, even if insulin remains.

Humalog Mix 75-25 (U-100) Insulin Subcutaneous : Uses

  1. Direct comparison of Humalog Mix50/50 and Humulin 50/50 was not performed. However, a cross-study comparison shown in Figure 1 suggests that Humalog Mix50/50 has a more rapid absorption than Humulin 50/50.
  2. e suspension and 25% insulin lispro) -Humalog Mix 50/50 (50% insulin lispro prota
  3. Smoking — The effect of smoking on the pharmacokinetics and pharmacodynamics of Humalog Mix50/50 has not been studied.

Note: Mean (SD) dose of insulin was 44.1 (18.2) U/day for Human Insulin 70/30; 44.1 (18.2) U/day for Humalog Mix75/25; and 43.8 (17.8) U/day for Humalog Mix50/50. Standard test breakfast: 500 kcal; 50% carbohydrate, 34% fat, 16% protein.The most common side effects of Humalog U-100, Humalog U-200, Humalog Mix75/25, Humalog Mix50/50, and Insulin Lispro Injection include: low blood sugar, allergic reactions, including reactions at your injection site, skin thickening or pits at the injection site (lipodystrophy), weight gain, swelling in your hands or feet, itching, and rash. These are not all of the possible side effects. Please see Important Safety Information for additional side effects. Ask your doctor for more information or for medical advice.Humalog® KwikPen® is a small, lightweight pen that’s prefilled with mealtime insulin. Plus, since it shouldn't be refrigerated after the first use, you can take it just about anywhere. You can carry it in your purse, backpack, or pocket because it’s the size of a marker. It’s a good idea to always carry an extra pen.

Humalog Mix 25 Kwikpen Inj 100u/ml 5PFPx3ml

Related treatment guides

Store all unopened (unused) Humalog Mix50/50 in the original carton in a refrigerator at 36°F to 46°F (2°C to 8°C). Do not freeze.HUMALOG® Mix75/25™ and HUMALOG® Mix75/25™ KwikPen® are trademarks of Eli Lilly and Company. Humalog Mix25 se može primijeniti neposredno prije obroka. Kada je potrebno, Humalog Mix25 se može dati neposredno nakon obroka. Humalog Mix25 se smije davati samo supkutanom injekcijom. Humalog Mix25 se ni pod kojim uvjetima ne smije primijeniti intravenski. Supkutanu injekciju treba dati u nadlakticu, bedro, stražnjicu ili abdomen As with other insulins, the requirements for Humalog Mix50/50 may be reduced in patients with renal impairment. Humalog Mix50/50 and Humalog Mix75/25 are known as insulin lispro protamine and insulin lispro injectable suspension. Humalog Mix50/50 and Humalog Mix75/25 are mixed insulins. This means they contain a mix of fast-acting and intermediate-acting insulins

Once you start using Humalog KwikPen, it should be stored at room temperature, below 86°F (30°C), and must be used within 10 days or be discarded, even if it still contains Humalog.Your doctor can prescribe a glucagon emergency injection kit to use in case you have severe hypoglycemia and cannot eat or drink. Be sure your family and close friends know how to give you this injection in an emergency. Close Account Sign In Register Now Drugs A-Z A-Z Drug Index Treatment Options Drugs by Class Compare Drugs Generic Drugs OTC Drugs International Drugs Natural Products Drug Side Effects Dosage Guides Pregnancy Warnings Breastfeeding Warnings Pricing & Coupons Inactive Ingredients Info en Español Veterinary Products Pill Identifier Interactions Checker News & Alerts Pro Edition More Drugs A to Z Insulin lispro/insulin lispro protamine Dosage Print Share Insulin Lispro / Insulin Lispro Protamine Dosage Medically reviewed by Drugs.com. Last updated on Apr 6, 2020. Geriatric Use: Dose selection should be cautious, usually starting at the low end of the dosing range reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease, or other drug therapies. -Daily insulin requirements may be higher during illness, stress, pregnancy, in obese patients, trauma, during concurrent use with medications having hyperglycemic effects, or after surgery -Daily insulin requirements may be lower with exercise, weight loss, calorie restricted diets, or during concurrent use of medications having hypoglycemic effects. Supplemental doses may be prescribed during illness Patients with type 2 diabetes receiving oral medications may be switched to insulin therapy temporarily. Dosage adjustments may be required when the brand, type, or species of insulin is changed; oral antidiabetic treatment may need to be adjusted as well.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

How to use Humalog Mix 75-25 Vial

Obesity — The effect of obesity and/or subcutaneous fat thickness on the pharmacokinetics and pharmacodynamics of Humalog Mix50/50 has not been studied. In large clinical trials, which included patients with Body Mass Index up to and including 35 kg/m2, no consistent differences were observed between Humalog and Humulin® R with respect to postprandialglucose parameters. HUMALOG MIX50/50 prescription and dosage sizes information for physicians and healthcare professionals. Pharmacology, adverse reactions, warnings and side effects Patients should be informed of the potential risks and advantages of Humalog Mix50/50 and alternative therapies. Patients should not mix Humalog Mix50/50 with any other insulin. They should also be informed about the importance of proper insulin storage, injection technique, timing of dosage, adherence to meal planning, regular physical activity, regular blood glucose monitoring, periodic hemoglobin A1c testing, recognition and management of hypo- and hyperglycemia, and periodic assessment for diabetes complications.In a glucose clamp study performed in 30 nondiabetic subjects, the onset of action and glucose-lowering activity of Humalog, Humalog Mix50/50, Humalog® Mix75/25™, and insulin lisproprotamine suspension (NPL component) were compared (see Figure 2). Graphs of mean glucoseinfusion rate versus time showed a distinct insulin activity profile for each formulation. The rapid onset of glucose-lowering activity characteristic of Humalog was maintained in Humalog Mix50/50.

Buy Humalog Mix 25 KwikPens Online - Low Cost From Canada

The following dosing options for patients with type 2 diabetes starting premixed insulin are based on Hirsch et al.7 Dosing guidelines should be individualized for each patient.Copyright © 2018 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. See additional information.Humalog Mix50/50 is a mixture of fast-acting and longer-acting man-made insulins. Humalog Mix50/50 is used to control high blood sugar (glucose) in people with diabetes.This medication passes into breast milk, but is unlikely to harm a nursing infant. Consult your doctor before breast-feeding. Your insulin needs may change while breast-feeding. 90 separated from the liquid after mixing. Do not use a Humalog Mix75/25 Pen if there are clumps 91 in the insulin after mixing. Do not use a Humalog Mix75/25 Pen if solid white particles stick to 92 the bottom or wall of the cartridge, giving a frosted appearance. Always check the appearance of 93 the Humalog Mix75/25 suspension before using

Humalog Mix 50/50 Pens - patient information, description

Do not use after the expiration date. Protect from direct heat and light. Do not freeze. See storage table below:The most common side effects of Humalog U-100, Humalog U-200, Humalog Mix75/25, Humalog Mix50/50, and Insulin Lispro Injection include: low blood sugar, allergic reactions, including reactions at your injection site, skin thickening or pits at the injection site (lipodystrophy), weight gain, swelling in your hands or feet, itching, and rash. These are not all of the possible side effects.

Humapen Luxura & Luxura Half Dial Pens for Injecting

Humalog Mix 75/25 - FDA prescribing information, side

  1. e is an *intermediate-acting* insulin. This combination insulin starts to work within 10 to 20
  2. If HUMALOG U-100 is mixed with NPH insulin, HUMALOG U-100 should be drawn into the syringe first. Injection should occur immediately after mixing. HUMALOG U-100 continuous subcutaneous infusion route (Insulin Pump) Do NOT mix HUMALOG U-100 with any other insulin. HUMALOG U-200 subcutaneous injection route: Do NOT mix with any other insulin
  3. Please see Humalog U-100 KwikPen Instructions for Use / Humalog Junior KwikPen Instructions for Use / Humalog U-100 Vial Instructions for Use / Humalog U-200 KwikPen Instructions for Use / Humalog Mix75/25 KwikPen Instructions for Use / Humalog Mix75/25 Vial Instructions for Use / Humalog Mix50/50 KwikPen Instructions for Use / Humalog Mix50/50 Vial Instructions for Use / Insulin Lispro Injection KwikPen Instructions for Use / Insulin Lispro Injection Vial Instructions for Use included with your pen.
  4. Pregnant rats and rabbits were exposed to insulin lispro in animal reproduction studies during organogenesis. No adverse effects on embryo/fetal viability or morphology were observed in offspring of rats exposed to insulin lispro at a dose approximately 3 times the human subcutaneous dose of 1 unit insulin lispro/kg/day. No adverse effects on embryo/fetal development were observed in offspring of rabbits exposed to insulin lispro at doses up to approximately 0.2 times the human subcutaneous dose of 1 unit/kg/day (see Data).

Insulin Lispro / Insulin Lispro Protamine Dosage Guide

Diabetes Treatment Humalog® (insulin lispro injection

If you have any questions or problems with your HUMALOG Mix50/50 KwikPen, contact Lilly at 1-800-Lilly-Rx (1-800-545-5979) or call your healthcare provider for help. For more information on HUMALOG Mix50/50 KwikPen and insulin, go to www.humalog.com.Male fertility was not compromised when male rats given subcutaneous insulin lispro injections of 5 and 20 units/kg/day (0.8 and 3 times the human subcutaneous dose of 1 unit insulin lispro/kg/day, based on units/body surface area) for 6 months were mated with untreated female rats. In a combined fertility, perinatal, and postnatal study in male and female rats given 1, 5, and 20 units/kg/day subcutaneously (0.2, 0.8, and 3 times the human subcutaneous dose of 1 unit insulin lispro/kg/day, based on units/body surface area), mating and fertility were not adversely affected in either gender at any dose.CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

Prescribing 75/25 and 50/50 Mixes Humalog

Humalog Mix 50-50 (Insulin Lispro): Uses, Dosage, Side

Humalog vs. Novolog: Important Differences and Mor

The rapid onset and early peak of activity of Humalog itself is observed following the subcutaneous administration of Humalog Mix25. This allows Humalog Mix25 to be given very close to mealtime. The duration of action of the insulin lispro protamine suspension component of Humalog Mix25 is similar to that of a basal insulin (NPH [isophane]) Read the patient information leaflet provided by your pharmacist before you start using this medication and each time you get a refill. If you have any questions, consult your doctor or pharmacist.Humalog and Insulin Lispro Injection are used to treat people with diabetes for the control of high blood sugar. Humalog Mix75/25 and Humalog Mix50/50 are used to treat adults with diabetes for the control of high blood sugar.

Humalog Mix 75/25 KwikPen Uses, Side Effects & Warnings

Humalog Mix 50/50 (50% Insulin Lispro Protamine Suspension, 50% Insulin Lispro Injection (rDNA) The estimated background risk of major birth defects is 6-10% in women with pre-gestational diabetes with a HbA1c >7 and has been reported to be as high as 20-25% in women with a HbA1c >10. The estimated background risk of miscarriage for the indicated population is unknown. In the U.S. general population, the estimated background risk of major birth defects and miscarriage in clinically recognized pregnancies is 2-4% and 15-20%, respectively.For full storage and disposal information, please see the Patient Information leaflet that comes with your insulin.The proportions of rapid-acting and intermediate-acting insulins in HUMALOG Mix75/25 are fixed and do not allow for basal versus prandial dose adjustments. Humalog adalah obat. Cari tahu informasi medis lengkap dan terverifikasi tentang fungsi Humalog, efek samping, keamanan, interaksi, dan peringatannya di Hello Sehat

NovoLog Mix 70/30 FlexPen

Humalog Mix 25 - Drugs

The risk of hypoglycemia after an injection is related to the duration of action of the insulin and in general, is highest when the glucose lowering effect of the insulin is maximal. As with all insulin preparations, the glucose lowering effect time course of HUMALOG Mix75/25 may vary in different individuals or at different times in the same individual and depends on many conditions, including the area of injection as well as the injection site blood supply and temperature [see Clinical Pharmacology (12.2)]. Other factors which may increase the risk of hypoglycemia include changes in meal pattern (e.g., macronutrient content or timing of meals), changes in level of physical activity, or changes to co-administered medication [see Drug Interactions (7)]. Patients with renal or hepatic impairment may be at higher risk of hypoglycemia [see Use in Specific Populations (8.6, 8.7)].Accidental mix-ups between HUMALOG Mix75/25 and other insulin products have been reported. To avoid medication errors between HUMALOG Mix75/25 and other insulins, instruct patients to always check the insulin label before each injection.Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Insulin overdose can cause life-threatening hypoglycemia. Symptoms include drowsiness, confusion, blurred vision, numbness or tingling in your mouth, trouble speaking, muscle weakness, clumsy or jerky movements, seizure (convulsions), or loss of consciousness.Do not share your needles or syringes with other people, even if the needle has been changed. You may give other people a serious infection or get a serious infection from them.Figure 3: Insulin Activity After Subcutaneous Injection of Humalog Mix50/50 and Humulin 50/50 in Nondiabetic Subjects.

Yes, you need to prime your pen. If you do not prime, you may get too much or too little insulin. You will turn the dose knob to 2 units. Hold your pen with the needle pointing up. Tap the cartridge holder gently to collect air bubbles at the top. Continue holding your pen with the needle pointing up. Push the dose knob in until it stops and zero is seen in the dose window. Hold the dose knob in and count to 5 slowly. You should see insulin at the tip of the needle.The effect of hepatic impairment on the pharmacokinetics of HUMALOG Mix75/25 has not been studied. Patients with hepatic impairment may be at increased risk of hypoglycemia and may require more frequent HUMALOG Mix75/25 dose adjustment and more frequent glucose monitoring [see Warnings and Precautions (5.3)]. Humalog Mix 25 is used to treat Diabetes. Read about Humalog Mix 25 Kwikpen 100IU/ml uses, side effects, dosage, price, composition and substitutes. It is manufactured by Eli Lilly and Company India. Popularly searched for Humalog Mix 2

Humalog Mix is used to improve blood sugar control in adults with diabetes mellitus. This medicine may be used for type 1 or type 2 diabetes. Humalog Mix may also be used for purposes not listed in this medication guide. Important information. Use Humalog Mix within 15 minutes before eating a meal mix Humalog U-200, Humalog Mix50/50, Humalog Mix75/25, or Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 with other insulins or liquids

Comparing Types of Insulin Humalog

Tell your healthcare provider about all of your medical conditions and all of the medicines you take, including if you:During times of stress, such as fever, infection, injury, or surgery, it may be more difficult to control your blood sugar. Consult your doctor because a change in your treatment plan may be required.Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Humalog Mix only for the indication prescribed.HUMALOG Mix75/25 (insulin lispro protamine and insulin lispro injectable suspension) is a mixture of 75% insulin lispro protamine, an intermediate-acting human insulin analog, and 25% insulin lispro, a rapid-acting human insulin analog. Insulin lispro is produced by recombinant DNA technology utilizing a non-pathogenic laboratory strain of Escherichia coli. Insulin lispro differs from human insulin in that the amino acid proline at position B28 is replaced by lysine and the lysine in position B29 is replaced by proline. Chemically, it is Lys(B28), Pro(B29) human insulin analog and has the empirical formula C257H383N65O77S6 and a molecular weight of 5808, both identical to that of human insulin. Insulin lispro protamine suspension is a suspension of crystals produced from combining insulin lispro and protamine sulfate under appropriate conditions for crystal formation. Humalog (insulin lispro) is a short-acting type of insulin.Insulin helps to control blood sugar levels in diabetes mellitus, including diabetes type 1 and diabetes type 2.Humalog is more popular than other insulins. Check our savings tips for co-pay cards, assistance programs, and other ways to reduce your cost.The most common version of Humalog is covered by 85% of insurance plans at a co-pay.

Marketed by: Lilly USA, LLC, Indianapolis, IN 46285, USA Copyright © 1999, 2019, Eli Lilly and Company. All rights reserved.Note: PAIR-PI average (standard deviation) daily dose of insulin was 0.42 (0.20) U/kg for Humalog Mix75/25 vs 0.36 (0.18) U/kg for glargine (P<.001).

HUMALOG is a sterile, aqueous, clear, and colorless solution. Each milliliter of HUMALOG U-100 contains insulin lispro 100 units, 16 mg glycerin, 1.88 mg dibasic sodium phosphate, 3.15 mg Metacresol, zinc oxide content adjusted to provide 0.0197 mg zinc ion, trace amounts of phenol, and Water for Injection.Insulin lispro has a pH of 7.0 to 7.8 Localized cutaneous amyloidosis at the injection site has occurred. Hyperglycemia has been reported with repeated insulin injections into areas of localized cutaneous amyloidosis; hypoglycemia has been reported with a sudden change to an unaffected injection site.

Do not inject cold insulin because this can be painful. The insulin container you are currently using can be kept at room temperature (see also Storage section). Wash your hands before measuring and injecting insulin. Check the product visually for particles, thickening, or clumps before rolling and turning the container. If any are present, discard that container.HUMALOG Mix75/25 KwikPens must never be shared between patients, even if the needle is changed. Patients using HUMALOG Mix75/25 vials must never share needles or syringes with another person. Always use a new disposable syringe or needle for each injection to prevent contamination.Blood sugar levels can be affected by stress, illness, surgery, exercise, alcohol use, or skipping meals. Ask your doctor before changing your dose or medication schedule.Humalog Mix75/25 and Humalog Mix50/50 may be injected under the skin of the stomach area, back of upper arms, upper legs, or buttocks (see diagram). Never inject Humalog mixes into a muscle or vein. Work with your doctor to determine the most appropriate injection sites. HUMALOG Mix75/25 is easier to mix when it is at room temperature. After mixing HUMALOG Mix75/25, inject your dose right away. If you wait to inject your dose, the insulin will need to be mixed again. Always use a new syringe and needle for each injection to help prevent infections and blocked needles

Contact Lilly Humalog

In an embryo-fetal development study in pregnant rabbits, insulin lispro doses of 0.1, 0.25, and 0.75 unit/kg/day (0.03, 0.08, and 0.2 times the human subcutaneous dose of 1 unit insulin lispro/kg/day, based on units/body surface area, respectively) were injected subcutaneously on Gestation days 7 through 19. There were no adverse effects on fetal viability, weight, and morphology at any dose. Lilly Humalog Mix25 KwikPen Manuals & User Guides. User Manuals, Guides and Specifications for your Lilly Humalog Mix25 KwikPen Insulin Pen. Database contains 1 Lilly Humalog Mix25 KwikPen Manuals (available for free online viewing or downloading in PDF): Operation & user's manual Humalog Mix50/50 should be inspected visually before use. Humalog Mix50/50 should be used only if it appears uniformly cloudy after mixing. Humalog Mix50/50 should not be used after its expiration date.Any change of insulin should be made cautiously and only under medical supervision.Changes in insulin strength, manufacturer, type (e.g., Regular, NPH, analog), species, or method of manufacture may result in the need for a change in dosage.

Humalog 75-25 (75-25 Insulin Lispro Suspension and 25

Humalog Mix50/50 is intended only for subcutaneous administration. Humalog Mix50/50 should not be administered intravenously. Dosage regimens of Humalog Mix50/50 will vary among patients and should be determined by the healthcare provider familiar with the patient's metabolic needs, eating habits, and other lifestyle variables. Humalog has been shown to be equipotent to Regular human insulin on a molar basis. One unit of Humalog has the same glucose-lowering effect as one unit of Regular human insulin, but its effect is more rapid and of shorter duration. The quicker glucose-lowering effect of Humalog is related to the more rapid absorption rate of insulin lispro from subcutaneous tissue.Safety and effectiveness of HUMALOG Mix75/25 in patients less than 18 years of age has not been established.Too little insulin can cause high blood sugar (hyperglycemia). Symptoms of high blood sugar include thirst, increased urination, confusion, drowsiness, flushing, rapid breathing, or fruity breath odor. If these symptoms occur, tell your doctor right away. Your treatment plan may need to be changed.

Humalog Mix50/50 and Humalog Mix75/25 are mixed insulins. This means they contain a mix of fast-acting and intermediate-acting insulins. They are used to control high blood sugar in people with diabetes. They are available only with a prescription. It is not known if Humalog Mix50/50 or Humalog Mix75/25 are safe and effective for children. Figures 1 and 2 should be considered only as representative examples since the time course of action of insulin and insulin analogs, may vary in different individuals or within the same individual.Humalog® Mix50/50™ [50% insulin lispro protamine suspension and 50% insulin lispro injection, (rDNA origin)] is a mixture of insulin lispro solution, a rapid-acting blood glucose-lowering agent and insulin lispro protamine suspension, an intermediate-acting blood glucose-lowering agent. Chemically, insulin lispro is Lys(B28), Pro(B29) human insulin analog, created when the amino acids at positions 28 and 29 on the insulin B-chain are reversed. Insulin lispro is synthesized in a special non-pathogenic laboratory strain of Escherichia coli bacteria that has been genetically altered to produce insulin lispro. Insulin lispro protamine suspension (NPL component) is a suspension of crystals produced from combining insulin lispro and protamine sulfate under appropriate conditions for crystal formation. Composición de HUMALOG / HUMALOG MIX 25. Cada ml de HUMALOG® contiene: Insulina Lispro (origen ADN recombinante) 100 U. Excipientes (Fosfato dibásico de sodio, glicerol, metacresol, Oxido de Zinc y agua para inyectables) c.s.p. 1.0 ml. Durante la elaboración se puede haber agregado solución de hidróxido de sodio al 10% o solución de ácido clorhídrico al 10% para ajustar el pH Humalog Mix should look cloudy. Do not use the medicine if it looks clear or has particles in it. Call your pharmacist for new medicine.

Insulin is injected under the skin. You will be shown how to use injections at home. Do not give yourself Humalog Mix if you do not understand how to use the injection and properly dispose of used needles and syringes. Do not inject Humalog Mix into a vein. The Humalog solution should be clear and colourless. Humalog should not be used if it appears cloudy, thickened, or slightly coloured or if solid particles are visible. Do not mix insulin in vials with insulin in cartridges. See section 6.2. Preparing a dose. Vial. The vial is to be used in conjunction with an appropriate syringe (100 unit. Rotate between typical injection sites, such as the abdomen, buttocks, upper legs, or upper arms. View the Instructions for Use for more information.Please click to access Humalog Full Prescribing Information, Humalog Mix75/25 Full Prescribing Information, Humalog Mix50/50 Full Prescribing Information, and Insulin Lispro Injection Full Prescribing Information.

Long-term studies in animals have not been performed to evaluate the carcinogenic potential of Humalog, Humalog Mix75/25, or Humalog Mix50/50. Insulin lispro was not mutagenic in a battery of in vitro and in vivo genetic toxicity assays (bacterial mutation tests, unscheduled DNA synthesis, mouse lymphoma assay, chromosomal aberration tests, and a micronucleus test). There is no evidence from animal studies of impairment of fertility induced by insulin lispro.Radiolabeled distribution studies of Humalog Mix50/50 have not been conducted. However, the volume of distribution following injection of Humalog is identical to that of Regular human insulin, with a range of 0.26 to 0.36 L/kg. HUMALOG Mix50/50 is easier to mix when it is at room temperature. After mixing HUMALOG Mix50/50, inject your dose right away. If you wait to inject your dose, the insulin will need to be mixed again. Always use a new syringe and needle for each injection to help prevent infections and blocked needles Poorly controlled diabetes in pregnancy increases the maternal risk for diabetic ketoacidosis, pre-eclampsia, spontaneous abortions, preterm delivery, and delivery complications. Poorly controlled diabetes increases the fetal risk for major birth defects, still birth, and macrosomia related morbidity.

Humalog (Insulin Lispro) - Side Effects, Dosage

The effect of renal impairment on the pharmacokinetics of HUMALOG Mix75/25 has not been studied. Patients with renal impairment may be at increased risk of hypoglycemia and may require more frequent HUMALOG Mix75/25 dose adjustment and more frequent glucose monitoring [see Warnings and Precautions (5.3)]. Eli Lilly brand name for their mix of 25% insulin lispro and 75% insulin lispro protamine suspension.Also known as Humalog Mix 25, it is an intermediate-acting insulin.The 75% fraction that is NPL (Neutral Protamine Lispro) is a suspension of crystals formed by combining insulin lispro and protamine. A study of dogs from 1993-1994 using various fractions of Humalog mixes against human NPH. Published data from retrospective studies and meta-analyses do not report an association with insulin lispro and major birth defects, miscarriage, or adverse maternal or fetal outcomes when insulin lispro is used during pregnancy. However, these studies cannot definitely establish or exclude the absence of any risk because of methodological limitations including small sample size, selection bias, confounding by unmeasured factors, and some lacking comparator groups.

Insulin is only part of a complete treatment program that may also include diet, exercise, weight control, regular blood sugar testing, and special medical care. Follow your doctor's instructions very closely. Humalog® Mix 75/25 Humalog® Mix 50/50 Novolog® Mix 70/30 PREMIXED INSULIN with rapid- and ultra-long acting insulins Ryzodeg® 70/30 (degludec/aspart) Interchange Recommendations: Regular and Rapid-acting PREMIXED insulins may be interchanged with another PREMIXED insulin with a 20% reduction in the dos HUMALOG MIX75/25 prescription and dosage sizes information for physicians and healthcare professionals. Pharmacology, adverse reactions, warnings and side effects Humalog Mix50/50 provided improved postprandial control for patients after a standardized breakfast meal3

Table 1*: Summary of Pharmacodynamic Properties of Insulin Products (Pooled Cross-Study Comparison) Insulin Products Dose, U/kg Time of Peak Activity, Hours After Dosing Percent of Total Activity Occurring inthe First 4 Hours Humalog 0.3 2.4 (0.8 - 4.3) 70% (49 - 89%) Humulin R 0.32 (0.26 - 0.37) 4.4 (4.0 - 5.5) 54% (38 - 65%) Humalog Mix75/25 0.3 2.6 (1.0 - 6.5) 35% (21 - 56%) Humulin 70/30 0.3 4.4 (1.5 - 16) 32% (14 - 60%) Humalog Mix50/50 0.3 2.3 (0.8 - 4.8) 45% (27 - 69%) Humulin 50/50 0.3 3.3 (2.0 - 5.5) 44% (21 - 60%) NPH 0.32 (0.27 - 0.40) 5.5 (3.5 - 9.5) 14% (3.0 - 48%) NPL component 0.3 5.8 (1.3 - 18.3) 22% (6.3 - 40%) * The information supplied in Table 1 indicates when peak insulin activity can be expected and the percent of the total insulin activity occurring during the first 4 hours. The information was derived from 3 separate glucose clamp studies in nondiabetic subjects. Values represent means, with ranges provided in parentheses. Savings Available for 800+Brand Name Medications! Get Medications at Little-to-No Cost. Start Saving Today What are Humalog Mix 50/50 Cartridges? Humalog Mix 50/50 Cartridges contain insulin lispro, which is a genetically engineered insulin analog. Humalog 50/50 is a mixture of 50% fast-acting insulin and 50% longer-acting insulin; it is a man-made insulin {{configCtrl2.info.metaDescription}} continuous subcutaneous insulin infusion (CSII) via a pump using a rapid-acting insulin preparation (lispro, aspart, glulisine).Mealtime boluses plus additional insulin used to correct hyperglycemia are provided in patients with pump malfunction who are using insulin lispro rather than regular insulin

This leaflet summarized the most important information about Humalog Mix50/50. If you would like more information about Humalog Mix50/50 or diabetes, talk with your healthcare provider. You can ask your healthcare provider or pharmacist for information about Humalog Mix50/50 that is written for healthcare providers.Do not store the Pen with the Needle attached to prevent leaking, blocking of the Needle, and air from entering the Pen.

In 31 healthy subjects given subcutaneous doses (0.3 unit/kg) of HUMALOG Mix75/25, the median peak serum concentration was 60 minutes (range: 30 minutes to 4 hours) after dosing. Identical results were found in patients with type 1 diabetes. The rapid absorption characteristics of HUMALOG are maintained with HUMALOG Mix75/25. HUMALOG Mix75/25 has a more rapid absorption than HUMULIN 70/30, which has been confirmed in patients with type 1 diabetes.Humalog Mix50/50 is contraindicated during episodes of hypoglycemia and in patients sensitive to insulin lispro or any of the excipients contained in the formulation.

You should see “0” in the Dose Window. If you do not see “0” in the Dose Window, you did not receive your full dose. 12. Product information for Novolog Mix 70/30. Novo Nordisk Inc. Princeton, NJ 08540. March 2008. 13. Product information for Humalog Mix 75/25. Eli Lilly and Company. Indianapolis, IN 46285. March 2009. 14. Rosenstock J, Davies M, Home PD, et al. A randomized, 52-week, treat-to-target trial comparing insulin detemir with insulin glargine whe Glucagon HypoKit. Humalog Cartridge (Insulin Lispro) Humalog Junior KwikPen (Insulin Lispro) Humalog KwikPen 100 (Insulin Lispro) Humalog KwikPen 200 (Insulin Lispro. Keep out of the reach of children. Unopened Vials: Humalog Mix 50/50 or Humalog Mix 75/25: Store in a refrigerator between 2 and 8 degrees C (36 and 46 degrees F) or at room temperature below 30 degrees C (86 degrees F). Do not freeze or use if the insulin has been frozen. Protect from light and excessive heat

Metabolism — Human metabolism studies of HUMALOG Mix75/25 have not been conducted. However, studies in animals indicate that the metabolism of HUMALOG, the rapid-acting component of HUMALOG Mix75/25, is identical to that of regular human insulin.Store the injection pen at room temperature (do not refrigerate) and use within 10 days. Do not store the injection pen with a needle attached.The effects of age, race, obesity, pregnancy, smoking, or renal or hepatic impairment on the pharmacokinetics of HUMALOG Mix75/25 have not been studied.Humalog Mix50/50 has two absorption phases, a rapid and a prolonged phase, representative of the insulin lispro and insulin lispro protamine suspension components of the mixture. As with other intermediate-acting insulins, a meaningful terminal phase half-life cannot be calculated after administration of Humalog Mix50/50 because of the prolonged insulin lispro protamine suspension absorption.Note: PAIR-IN average (standard deviation) daily dose of insulin was 0.62 (0.37) U/kg for Humalog Mix75/25 vs 0.57 (0.37) U/kg for glargine (P<.001).

Humalog is the brand name for a fast-acting insulin called insulin lispro.. Humalog Mix 75/25, and Humalog Mix 50/50, contain mixtures of insulin lispro along with a second form of insulin called. Antibody Production — In clinical trials, antibodies that cross-react with human insulin and insulin lispro were observed in both human insulin mixtures and insulin lispro mixtures treatment groups.

Human metabolism studies of Humalog Mix50/50 have not been conducted. Studies in animals indicate that the metabolism of Humalog, the rapid-acting component of Humalog Mix50/50, is identical to that of Regular human insulin.Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Humalog synonyms, Humalog pronunciation, Humalog translation, English dictionary definition of Humalog. Humulin R, Novolin R, Humulin N, Novolin N, Levemir, Lantus, Humalog Mix, Novolog Mix, and Others), By Distribution Channel (Hospital Pharmacies, Retail Pharmacies, and Online Pharmacies) was valued US$ 27.4 billion in 2018, and is. Insulin lispro, the rapid-acting component of Humalog Mix50/50, has been shown to be equipotent to Regular human insulin on a molar basis. One unit of Humalog® has the same glucose-lowering effect as one unit of Regular human insulin, but its effect is more rapid and of shorter duration.

Unopened Humalog should be stored in a refrigerator and can be used until the expiration date on the carton or label.Reproduction studies with insulin lispro have been performed in pregnant rats and rabbits at parenteral doses up to 4 and 0.3 times, respectively, the average human dose (40 units/day) based on body surface area. The results have revealed no evidence of impaired fertility or harm to the fetus due to insulin lispro. There are, however, no adequate and well-controlled studies with Humalog, Humalog Mix75/25, or Humalog Mix50/50 in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. Mixing by rolling and inverting the Pen is importantto make sure you get the right dose. After mixing HUMALOG Mix75/25, inject your dose right away. If you wait to inject your dose, the insulin will need to be mixed again. Step 4: • Check the liquid in the Pen. HUMALOGMix75/25 should look white and cloudy after mixing. Do notuse if i Each milliliter of HUMALOG Mix75/25 injection contains insulin lispro 100 units, 0.28 mg protamine sulfate, 16 mg glycerin, 3.78 mg dibasic sodium phosphate, 1.76 mg Metacresol, zinc oxide content adjusted to provide 0.025 mg zinc ion, 0.715 mg phenol, and Water for Injection. The pH is 7.0 to 7.8. Sodium hydroxide and/or hydrochloric acid may be added during manufacture to adjust the pH. What is HUMALOG MIX 75-25?Overview|Dosage|Warnings|Side Effects. Insulin lispro protamine/insulin lispro is used along with a proper diet and exercise program to control high blood sugar in people with diabetes. This product is a combination of two man-made insulins: intermediate-acting insulin lispro protamine and rapid-acting insulin lispro As with all therapeutic peptides, insulin administration may cause anti-insulin antibodies to form. The incidence of antibody formation with HUMALOG Mix75/25 is unknown.

  • Delta fluss.
  • Hirntot records discography download.
  • Sprüche lästern neid.
  • 6. monat welche woche.
  • Kein beep mit ram.
  • Wertvollste fußballvereine 2019.
  • Beste bank für umschuldung.
  • Taschen für lehrerinnen.
  • Kabarett theater sanftwut.
  • Manau holz.
  • Musiksender astra.
  • The legend of the blue sea ger sub.
  • Baby laufen lernen zehenspitzen.
  • Verstärker für deckenlautsprecher.
  • Gebet zur mutter der gesundheit.
  • Solar akku aa 300mah.
  • Aminosäuren wirkung haarausfall.
  • Gellertberg budapest.
  • Hacklberger bier kasten preis.
  • Uni jena partneruniversitäten medizin.
  • Iphone 6 taschenlampe geht nicht.
  • Was dürfen lehrer nicht machen schweiz.
  • Byblos shisha.
  • Guk fortbildung 2019 berlin.
  • Technische null.
  • Berufliche massnahmen iv basel.
  • Zayn malik album.
  • Songtext hercules in sekunden auf 100.
  • Junghans max bill glas ersetzen kosten.
  • Noz urlaubsservice telefonnummer.
  • Benimmregeln ukraine.
  • Idea jobs.
  • Galeria mobil.
  • Destiny 2 serverwartung heute.
  • Gebet zur mutter der gesundheit.
  • Golf 7 gti klappenauspuff mit tüv.
  • Timney remington 700 tactical trigger.
  • Assassins creed black flag was ist ein jagdschiff.
  • Stars unter 18.
  • Iss pyaar ko kya naam doon full episodes.
  • Sims 4 vorteilspunkte cheat tierklinik.